Related Experiment Video
Updated: May 20, 2026
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Developments in liver transplantation for hepatocellular carcinoma
Emmanuel Melloul1, Mickael Lesurtel, Brian I Carr
1Department of Surgery, Swiss Hepato-Pancreato-Biliary and Transplantation Center, University Hospital Zurich, Zurich, Switzerland.
Seminars in Oncology
|August 1, 2012
Summary
Liver transplantation (LT) offers a curative option for hepatocellular carcinoma (HCC) by removing the tumor and diseased liver. Strict selection criteria are crucial for successful LT outcomes in HCC patients.
Area of Science:
- Hepatology
- Surgical Oncology
- Transplant Surgery
Background:
- Hepatocellular carcinoma (HCC) poses a significant global health challenge, often linked to viral hepatitis.
- Liver transplantation (LT) is a primary treatment for HCC, addressing both the malignancy and the underlying liver disease.
Purpose of the Study:
- To provide an updated review on liver transplantation for HCC.
- To focus on critical aspects including selection criteria, diagnostic advancements, and prognostic indicators.
Main Methods:
- Review of current literature and clinical practices in LT for HCC.
- Analysis of diagnostic tools, prognostic factors, and therapeutic strategies.
Main Results:
- Early detection of HCC through improved imaging and surveillance enables effective treatment.
- Strict selection criteria based on tumor burden are essential for long-term LT success in HCC.
- Ongoing research addresses controversies in LT indications and organ allocation for HCC.
Conclusions:
- LT offers a viable treatment for select HCC patients, emphasizing the importance of stringent selection criteria.
- Further research is needed to optimize LT outcomes, including adjuvant therapies and immunosuppression strategies.
