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Related Experiment Video

Updated: May 20, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

DNA methylation based biomarkers: practical considerations and applications.

Alexandre How Kit1, Helene Myrtue Nielsen, Jörg Tost

  • 1Laboratory for Functional Genomics, Fondation Jean Dausset - CEPH, 27 rue Juliette Dodu, 75010 Paris, France.

Biochimie
|August 1, 2012
PubMed
Summary

DNA methylation biomarkers offer a promising, sensitive alternative to protein biomarkers for disease detection and treatment prediction. Further development is needed for broader clinical application.

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Area of Science:

  • Biomarker discovery
  • Epigenetics
  • Molecular diagnostics

Background:

  • Biomarkers are crucial for disease diagnosis, outcome prediction, and personalized treatment.
  • Protein biomarkers are widely used, but DNA methylation biomarkers show potential for enhanced specificity and sensitivity.
  • Epigenetic modifications, specifically DNA methylation, are stable, heritable, and detectable through various technologies.

Purpose of the Study:

  • To review the advantages of DNA methylation as a biomarker.
  • To discuss practical considerations for developing DNA methylation biomarkers.
  • To explore applications in disease detection, outcome prediction, and treatment response, focusing on cancer and other complex diseases.

Main Methods:

  • Review of existing literature on DNA methylation biomarkers.

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Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

Related Experiment Videos

Last Updated: May 20, 2026

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
13:47

Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

Published on: February 24, 2015

Targeted DNA Methylation Analysis by Next-generation Sequencing
08:38

Targeted DNA Methylation Analysis by Next-generation Sequencing

Published on: February 24, 2015

Methyl-binding DNA capture Sequencing for Patient Tissues
08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

  • Discussion of detection and quantification technologies for DNA methylation.
  • Analysis of clinical utility and challenges for DNA methylation biomarkers.

    • Main Results:

    • DNA methylation biomarkers can be detected in various sample types, including non-invasive body fluids.
    • In some cases, DNA methylation biomarkers demonstrate superior specificity and sensitivity compared to protein biomarkers.
    • Despite their potential, clinical translation and commercial availability of DNA methylation biomarkers remain limited.

    Conclusions:

    • DNA methylation represents a powerful biomarker class with significant potential in clinical diagnostics and personalized medicine.
    • Addressing practical development and validation challenges is key to realizing the full clinical utility of DNA methylation biomarkers.
    • Further research and development are warranted to expand the application of DNA methylation biomarkers in oncology, complex diseases, and prenatal diagnostics.