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Updated: May 20, 2026
09:20
Generation of Multicellular Human Primary Endometrial Organoids
Published on: October 4, 2019
Endometrial regeneration and endometrial stem/progenitor cells
Caroline E Gargett1, Hong P T Nguyen, Louie Ye
1The Ritchie Centre, Monash Institute of Medical Research, Clayton, Victoria, Australia. caroline.gargett@monash.edu
Reviews in Endocrine & Metabolic Disorders
|August 1, 2012
Summary
Human endometrial stem cells drive tissue regeneration monthly and after injury. These stem cells offer potential for treating gynecological diseases and regenerating tissues.
Area of Science:
- Reproductive biology
- Stem cell research
- Gynecology
Background:
- The human endometrium is a dynamic, regenerative tissue cycling monthly under hormonal influence.
- Postmenopausal endometrium retains regenerative capacity, responding to hormone therapy.
- Endometrial regeneration occurs after childbirth and surgery.
Purpose of the Study:
- To review evidence for endometrial stem/progenitor cells.
- To examine their role in endometrial repair and regeneration in mouse models.
- To discuss generation of endometrial epithelium from human embryonic stem cells and therapeutic applications.
Main Methods:
- Review of existing literature on endometrial stem cells.
- Analysis of mouse models for endometrial epithelial repair.
- Examination of estrogen-induced endometrial regeneration studies.
- Description of endometrial-like epithelium generation from human embryonic stem cells.
Main Results:
- Adult stem cells identified in human and mouse endometrium.
- Epithelial progenitor and mesenchymal stem/stromal cells are key to regeneration.
- Mouse models demonstrate roles in repair and estrogen-induced regeneration.
- Endometrial-like epithelium generated from human embryonic stem cells.
Conclusions:
- Endometrial stem/progenitor cells are crucial for cyclical regeneration.
- Mesenchymal stem/stromal cells may be involved in gynecological diseases.
- Potential applications in cell-based therapies for tissue regeneration exist.
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The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
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However, failure of such a system...
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