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Related Concept Videos

Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Cross-reactivity00:42

Cross-reactivity

Overview
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Related Experiment Video

Updated: May 20, 2026

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation
12:48

Purification of the Membrane Compartment for Endoplasmic Reticulum-associated Degradation of Exogenous Antigens in Cross-presentation

Published on: August 21, 2017

Cross-presentation of IgG-containing immune complexes.

Kristi Baker1, Timo Rath, Wayne I Lencer

  • 1Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

Cellular and Molecular Life Sciences : CMLS
|August 1, 2012
PubMed
Summary
This summary is machine-generated.

Immunoglobulin G (IgG) bridges innate and adaptive immunity by delivering antigens for T cell priming. This review explores how IgG immune complexes drive cross-presentation, impacting T cell responses and immune diseases.

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Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Immunoglobulin G (IgG) links innate and adaptive immunity.
  • IgG is produced by B cells, with or without T cell help.
  • Secreted IgG delivers antigens into processing pathways for T cell priming.

Purpose of the Study:

  • To review mechanisms of IgG-mediated antigen cross-presentation.
  • To explore IgG's role in delivering antigens into MHC class I pathways.
  • To discuss implications for immune-mediated diseases involving CD8(+) T cells.

Main Methods:

  • Review of existing literature on IgG function and immune complex mechanisms.
  • Analysis of IgG interaction with Fcγ receptors and FcRn.
  • Focus on antigen processing and presentation pathways.

Main Results:

  • IgG facilitates antigen delivery into both MHC class II and class I processing pathways.
  • Coordinated engagement of FcγR and FcRn enhances antigen cross-presentation.
  • IgG immune complexes are potent mediators of cross-presentation in dendritic cells.

Conclusions:

  • Understanding IgG-mediated cross-presentation is crucial for manipulating immune responses.
  • This mechanism impacts T cell activation, particularly CD8(+) T cells.
  • Implications for treating immune-mediated diseases driven by T cell activity.