Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cross-Sectional Research01:50

Cross-Sectional Research

In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
What are Populations and Communities?00:30

What are Populations and Communities?

Overview
Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
Cross-reactivity00:42

Cross-reactivity

Overview
Crossing Over01:30

Crossing Over

Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I, duplicated...
Crossing Over01:34

Crossing Over

Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process called synapsis.
In order to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applying Automated Artificial Intelligence Models on Lateral Cephalometric Parameters to Accurately Classify Arab Orthodontic Patient Patterns.

Clinical and experimental dental research·2026
Same author

Machine Learning and Clustering Analysis of Class II and III Malocclusions.

Clinical and experimental dental research·2026
Same author

Mapping Genetic Modifiers of Polyp Formation in <i>Smad4</i>-Deficient Juvenile Polyposis Using the Collaborative Cross Mouse Population.

Cells·2026
Same author

Non-Mendelian inheritance of DNA methylation patterns in mice.

Nature genetics·2026
Same author

Improve genetic quality control to increase rigor and reproducibility of mouse research.

Science (New York, N.Y.)·2026
Same author

Cross-coronavirus host susceptibility loci influence disease severity through immune mediators.

bioRxiv : the preprint server for biology·2026
Same journal

Correction: Are we fully exploiting genetic discoveries to understand and treat Alzheimer's disease?

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Neuroinflammation in glaucoma: a myriad of cellular pathways and players.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Correction: THBS1: a biomarker for PCOS and its role in pathogenesis via the PI3K/AKT signaling pathway.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

Elucidating the therapeutic targets and multi-target mechanisms of salvianolic acid A for diabetic nephropathy.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

DeepDisSNP: Predicting disease-associated SNPs by representation learning on disease and SNP linkage disequilibrium networks.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same journal

A comprehensive full-length transcriptome atlas across multiple organs of an Indian yak breed-Arunachali.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

Status and access to the Collaborative Cross population.

Catherine E Welsh1, Darla R Miller, Kenneth F Manly

  • 1Department of Computer Science, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|August 1, 2012
PubMed
Summary
This summary is machine-generated.

The Collaborative Cross (CC) mouse model is advancing genetic research. Efforts are underway to distribute these genetically diverse lines globally for broader scientific access and trait mapping.

More Related Videos

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Related Experiment Videos

Last Updated: May 20, 2026

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
11:21

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data

Published on: July 27, 2018

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research
11:18

Generation of Comprehensive Thoracic Oncology Database - Tool for Translational Research

Published on: January 22, 2011

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

Area of Science:

  • Genetics
  • Animal Models
  • Bioinformatics

Background:

  • The Collaborative Cross (CC) is a powerful panel of recombinant inbred mouse lines, crucial for genetic research.
  • Previous studies have utilized incompletely inbred CC mice for trait mapping, highlighting the need for fully inbred lines.
  • Diverse genetic backgrounds are essential for comprehensive genetic architecture studies.

Purpose of the Study:

  • To describe the distribution efforts for the Collaborative Cross (CC) genetic reference population.
  • To facilitate community access to well-defined CC lines for research purposes.
  • To outline the collaborative process among international breeding sites.

Main Methods:

  • Marker-assisted inbreeding is employed to accelerate the inbreeding process across multiple global sites (US, Israel, Australia).
  • Defined thresholds for inbreeding are established to ensure line quality and consistency.
  • Distribution centers are being established for streamlined access to CC lines.

Main Results:

  • Active collaboration among US, Israeli, and Australian breeding sites is accelerating CC line inbreeding.
  • Plans for distribution are in place, aiming to provide community access to the CC resource.
  • The UNC Systems Genetics Core, Tel Aviv University, and the University of Western Australia are key contributors to distribution efforts.

Conclusions:

  • The Collaborative Cross (CC) resource is nearing full inbreeding and is preparing for wider distribution.
  • Enhanced access to the CC population will empower genetic studies and trait mapping.
  • International collaboration is key to advancing the CC resource for the scientific community.