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Congenital anomalies and childhood celiac disease in Sweden

Carl Johan Wingren1, Daniel Agardh, Juan Merlo

  • 1Department of Clinical Sciences, Unit for Social Epidemiology, Lund University, Malmo, Sweden. carl_johan.wingren@med.lu.se

Journal of Pediatric Gastroenterology and Nutrition
|August 1, 2012
PubMed

Insights

Congenital anomalies, particularly chromosomal and digestive tract issues, increase the risk of childhood celiac disease (CD). This study confirms links between various birth defects and the development of CD.

Area of Science:

  • Pediatric Gastroenterology
  • Clinical Genetics
  • Epidemiology

Background:

  • Previous research suggests a link between congenital anomalies and an elevated risk of celiac disease (CD).
  • However, a comprehensive investigation into specific types of anomalies and their association with CD is warranted.

Purpose of the Study:

  • To systematically investigate the association between various congenital anomalies and the risk of developing childhood celiac disease (CD).
  • To utilize robust statistical methods, including sibling designs, to confirm these associations.

Main Methods:

  • A population-based cohort study identified 792,401 singleton children born in Sweden between 1987 and 1993.
  • Celiac disease (CD) cases were ascertained through the Swedish National Inpatient Registry.
  • Cox regression models and sibling designs were employed to analyze the association between congenital anomalies and childhood CD.

Main Results:

  • Congenital anomalies affecting the face, neck, ear, heart, digestive tract, and chromosomes were significantly associated with an increased risk of celiac disease (CD).
  • The study identified specific patterns of birth defects linked to CD development.

Conclusions:

  • Congenital anomalies, especially chromosomal and digestive tract anomalies, are confirmed risk factors for childhood celiac disease (CD).
  • These findings underscore the importance of considering birth defects in the context of CD risk assessment and management.

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