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Updated: May 20, 2026

Minimizing Hypoxia in Hippocampal Slices from Adult and Aging Mice
Published on: July 2, 2020
All about running: synaptic plasticity, growth factors and adult hippocampal neurogenesis
Carmen Vivar1, Michelle C Potter, Henriette van Praag
1Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, NIA/NIH Biomedical Research Center, Suite 100, 251 Bayview Blvd, Baltimore, MD, 21224, USA.
Abstract:
Accumulating evidence from animal and human research shows exercise benefits learning and memory, which may reduce the risk of neurodegenerative diseases, and could delay age-related cognitive decline. Exercise-induced improvements in learning and memory are correlated with enhanced adult hippocampal neurogenesis and increased activity-dependent synaptic plasticity. In this present chapter we will highlight the effects of physical activity on cognition in rodents, as well as on dentate gyrus (DG) neurogenesis, synaptic plasticity, spine density, neurotransmission and growth factors, in particular brain-derived nerve growth factor (BDNF).
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