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[The late results of treating membranous glomerulonephritis]
Abstract:
27 patients with membranous glomerulonephritis treated with corticosteroids, anticoagulants and some with immunosuppressors are discussed. Men prevailed. Nephrotic syndrome proved by renal biopsy was found in 88.9%, proteinuria under 3.5 g/24 h--in 11.1%, arterial hypertension--in 18.5%, renal failure--in 14.8% of the patients. At the end of the follow up 15 patients (55.6%) showed a complete remission and 4 patients a partial remission. In 8 patients (29.6%) there was chronic renal failure and three of them had gone through hemodialysis. Comparing the patients with and without chronic renal failure we found that only the presence of impaired renal function as found by renal biopsy and the greated duration of the disease are of statistically significant importance for the prognosis of membranous glomerulonephritis. A 5 year survival of the patients treated actively is 100% and a 10 year survival is 94.9% which allows the assumption that treatment of membranous glomerulonephritis can lead to a permanent remission and preservation of renal function.
Insights
Active treatment for membranous glomerulonephritis (MGN) leads to high remission rates and preserves kidney function. Early diagnosis and intervention are key for better prognosis in MGN patients.
Area of Science:
- Nephrology
- Internal Medicine
Context:
- Membranous glomerulonephritis (MGN) is a leading cause of nephrotic syndrome in adults.
- Treatment strategies for MGN vary, impacting patient outcomes.
Purpose:
- To evaluate the efficacy of active treatment for membranous glomerulonephritis.
- To identify prognostic factors influencing long-term outcomes in MGN patients.
Summary:
- This study analyzed 27 patients with membranous glomerulonephritis treated with corticosteroids, anticoagulants, and immunosuppressors.
- High rates of complete (55.6%) and partial (14.8%) remission were observed.
- Impaired renal function on biopsy and disease duration were significant prognostic factors.
- Long-term survival rates were high (100% at 5 years, 94.9% at 10 years).
Impact:
- Active treatment can lead to permanent remission and preserve renal function in MGN.
- Understanding prognostic factors aids in tailoring treatment and managing patient expectations.
- This research supports aggressive management strategies for membranous glomerulonephritis.