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Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

Excessive wave reflections on admission predict post-discharge events in patients hospitalized due to acute heart

Shih-Hsien Sung1, Wen-Chung Yu, Hao-Min Cheng

  • 1Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

European Journal of Heart Failure
|August 1, 2012
PubMed

Insights

Measures of wave reflection, including carotid augmented pressure (cAP), reflected pressure wave amplitude (Pb), and carotid pulse pressure (PP), predict long-term outcomes in acute heart failure syndrome (AHFS) patients. These findings highlight wave reflection's role in AHFS.

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Clinical Physiology

Background:

  • The role of arterial wave reflections in acute heart failure syndrome (AHFS) pathogenesis is not fully understood.
  • Predicting long-term prognosis in AHFS patients is crucial for effective management.

Purpose of the Study:

  • To investigate the long-term prognostic value of various wave reflection parameters on admission in hospitalized AHFS patients.
  • To assess the predictive power of carotid augmentation index (cAI), carotid augmented pressure (cAP), reflected pressure wave amplitude (Pb), and carotid pulse pressure (PP).

Main Methods:

  • 120 AHFS patients were enrolled, with measurements of cAI, cAP, Pb, carotid PP, cf-PWV, and TFC obtained within 24 hours of admission.
  • NT-proBNP levels were measured before discharge.
  • Patients were followed for a median of 601 days for adverse events.

Main Results:

  • In univariate analysis, all wave reflection measures significantly predicted post-discharge events.
  • Multivariate analysis revealed that cAP, Pb, and carotid PP independently predicted events after adjusting for clinical factors and NT-proBNP.
  • cAI, TFC, and cf-PWV did not show independent predictive value.

Conclusions:

  • On-admission cAP, Pb, and carotid PP are valuable for predicting long-term outcomes in AHFS patients.
  • These findings suggest a significant role for arterial wave reflections in the pathogenesis of AHFS.
  • Wave reflection parameters may aid in risk stratification for AHFS patients.
Abstract

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