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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Related Experiment Video

Updated: May 20, 2026

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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MicroRNAs in Human Malignant Gliomas.

Masahiro Mizoguchi1, Yanlei Guan, Koji Yoshimoto

  • 1Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Journal of Oncology
|August 1, 2012
PubMed
Summary

MicroRNAs (miRNAs) are key regulators of gene expression in glioblastoma. These small molecules are implicated in tumor growth, treatment resistance, and may serve as diagnostic markers and therapeutic targets.

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small noncoding RNA molecules regulating gene expression post-transcriptionally.
  • MiRNAs are involved in critical cellular processes including tumorigenesis, angiogenesis, invasion, and apoptosis.
  • Dysregulation of specific miRNAs is observed in various tumors, particularly malignant gliomas.

Purpose of the Study:

  • To summarize novel insights into the role of miRNAs in human malignant gliomas.
  • To highlight the clinical implications of miRNA dysregulation in glioblastoma.
  • To explore the potential of miRNAs as diagnostic markers and therapeutic targets.

Main Methods:

  • Global expression profiling of miRNAs in glioblastoma.
  • Review of recent studies investigating miRNA roles in glioblastoma.
  • Analysis of miRNA association with clinical outcomes and therapeutic resistance.

Main Results:

  • Specific miRNAs are clinically implicated in human glioblastomas.
  • Certain miRNAs correlate with patient outcomes and resistance to chemotherapy and radiotherapy.
  • MiRNAs regulate key signaling pathways and cancer stem cell properties in glioblastoma.

Conclusions:

  • MiRNAs are significant regulators in glioblastoma, impacting tumor progression and therapeutic responses.
  • MiRNAs show potential as diagnostic biomarkers for glioblastoma.
  • MiRNAs represent promising therapeutic targets for glioblastoma treatment.