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Related Experiment Video

Updated: May 20, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Stem cells as a tool for breast imaging.

Maria Elena Padín-Iruegas1, Rafael López López

  • 1Hospital Clínico Universitario c/Travesía Choupana s/n. E-15706, Santiago de Compostela, Spain.

Journal of Oncology
|August 1, 2012
PubMed
Summary
This summary is machine-generated.

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Stem cell research explores therapeutic potential, focusing on cancer stem cells and circulating tumor cells. Molecular imaging techniques like MRI and radionuclide imaging are crucial for understanding stem cell behavior in vivo.

Area of Science:

  • Stem cell biology
  • Cancer research
  • Molecular imaging

Background:

  • Stem cells possess therapeutic potential but are affected by senescence.
  • Cancer stem cells drive tumor heterogeneity and regeneration.
  • Circulating tumor cells can cause metastasis.

Purpose of the Study:

  • To review the role of molecular imaging in understanding stem cell behavior.
  • To highlight advancements in in vivo stem cell monitoring.

Main Methods:

  • Magnetic Resonance Imaging (MRI) for high-resolution morphological and functional data.
  • Radioscintigraphic techniques for high sensitivity and tissue penetration.
  • Radionuclide imaging as a direct labeling technique in human studies.

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Mammosphere Assay Reveals Api5-Induced Stemness in Non-Tumorigenic Breast Epithelial Cell Lines
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Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer
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Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer

Published on: February 8, 2013

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Last Updated: May 20, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Mammosphere Assay Reveals Api5-Induced Stemness in Non-Tumorigenic Breast Epithelial Cell Lines
08:05

Mammosphere Assay Reveals Api5-Induced Stemness in Non-Tumorigenic Breast Epithelial Cell Lines

Published on: February 24, 2026

Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer
11:47

Time-lapse Imaging of Primary Preneoplastic Mammary Epithelial Cells Derived from Genetically Engineered Mouse Models of Breast Cancer

Published on: February 8, 2013

Main Results:

  • Molecular imaging provides deeper insights into in vivo stem cell behavior.
  • MRI offers detailed spatial and temporal information.
  • Radioscintigraphy demonstrates picomolar sensitivity and clinical translatability.

Conclusions:

  • Molecular imaging is indispensable for preclinical and clinical stem cell studies.
  • MRI and radionuclide imaging are key modalities for stem cell research.
  • Direct labeling techniques are vital for human stem cell investigations.