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Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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A 3D Organotypic Melanoma Spheroid Skin Model
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Published on: May 18, 2018

Primary retroperitoneal malignant melanoma: A case report.

Guo-Bing Liu1, Guang-Yao Wu, Prasanna Ghimire

  • 1Department of MRI, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China.

Oncology Letters
|August 1, 2012
PubMed
Summary

Primary malignant melanoma, a rare cancer, was found in the retroperitoneum of an 18-year-old female. Investigations confirmed the retroperitoneum as the primary site, not a secondary location.

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Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Primary malignant melanoma typically arises in the skin.
  • Extracutaneous melanoma, originating outside the skin, is exceptionally rare.
  • Retroperitoneal tumors are uncommon, with melanoma being an even rarer primary entity in this location.

Purpose of the Study:

  • To report a rare case of primary malignant melanoma of the retroperitoneum.
  • To highlight the diagnostic challenges and confirm the primary origin of the tumor.
  • To contribute to the literature on rare oncological presentations.

Main Methods:

  • Case presentation of an 18-year-old female with retroperitoneal mass.
  • Surgical exploration with laparotomy and tissue biopsy.
  • Histopathological examination with immunohistochemical staining for diagnosis.
  • Extensive clinical and radiological investigations to determine the primary site.

Main Results:

  • Diagnosis of malignant melanoma confirmed via histopathology and immunohistochemistry.
  • Confirmed retroperitoneum as the primary site of the melanoma.
  • Ruled out metastatic disease from a cutaneous or other primary source.

Conclusions:

  • Primary retroperitoneal malignant melanoma is an exceedingly rare diagnosis.
  • Comprehensive diagnostic workup is crucial to establish the primary site of rare melanomas.
  • This case underscores the importance of considering unusual origins for malignant neoplasms.