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[Simultaneous determination of three components in compound clorprenaline tablet by using the
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1990
Summary
This study presents a new method for simultaneously analyzing clorprenaline hydrochloride, bromhexine hydrochloride, and decloxizine hydrochloride in tablets. The technique effectively overcomes spectral interferences for accurate quality control and dissolution research.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Context:
- Clorprenaline compound tablets contain clorprenaline hydrochloride, bromhexine hydrochloride, and decloxizine hydrochloride.
- Simultaneous determination of these components is challenging due to overlapping absorption spectra and low analyte concentrations.
- Existing analytical methods struggle with spectral interference, particularly from clorprenaline hydrochloride.
Purpose:
- To develop a robust analytical method for the simultaneous determination of three active pharmaceutical ingredients in clorprenaline compound tablets.
- To overcome spectral interferences caused by overlapping absorption bands.
- To provide a reliable method for quality control and dissolution studies.
Summary:
- A novel analytical method utilizing first-order derivative transformation and complementary tristimulus method with additions was developed.
- This approach effectively eliminates matrix interference, enabling accurate simultaneous quantification of clorprenaline hydrochloride, bromhexine hydrochloride, and decloxizine hydrochloride.
- A custom-developed software facilitates parameter selection and data reporting, including dissolution process visualization.
Impact:
- The method offers a valuable tool for quality control in pharmaceutical manufacturing.
- It supports research into the dissolution dynamics of tablets in simulated gastric environments.
- Enables more precise and efficient analysis of complex pharmaceutical formulations.