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[Studies on sensor for L-ascorbic acid using biotissue slice].

F Xu1, G L Shen, R Q Yu

  • 1Department of Chemical Engineering and Chemistry, Hunan University, Changsha.

Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1990
PubMed
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A novel bioselective membrane electrode using porcine liver tissue was developed for L-ascorbic acid detection. This biosensor demonstrates reliable performance in quantifying L-ascorbic acid in pharmaceutical samples.

Area of Science:

  • Biotechnology
  • Electrochemistry
  • Analytical Chemistry

Context:

  • Development of biosensors for accurate analyte quantification.
  • Need for sensitive and selective methods for L-ascorbic acid determination.
  • Utilization of biological tissues in electrochemical sensor design.

Purpose:

  • To create a bioselective membrane electrode for L-ascorbic acid (vitamin C) detection.
  • To investigate the impact of various parameters on electrode performance.
  • To evaluate the electrode's efficacy in real-world applications, such as drug analysis.

Summary:

  • A novel bioselective membrane electrode was fabricated using a porcine liver tissue slice covering an oxygen electrode.
  • The electrode's response characteristics were optimized by examining factors including buffer mediator, pH, temperature, and slice thickness.

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  • In the presence of copper ions, the electrode exhibited a linear dynamic response with the logarithm of L-ascorbic acid concentration (21.14–352.3 µg/mL), showing a high correlation coefficient (0.9996) and a Michaelis constant of 0.8 mmol/L.

    • Impact:

    • The developed electrode provides a reliable and satisfactory method for determining L-ascorbic acid in pharmaceutical formulations.
    • This research contributes to the advancement of biosensor technology for vitamin C analysis.
    • The findings highlight the potential of using biological tissues in the development of cost-effective and selective electrochemical sensors.