Related Experiment Videos
[Interferon-producing activity of bone marrow cells treated with mRNA for interferon when transplanted to irradiated
Abstract:
Inoculation into irradiated (800--850 r) mice of syngeneic bone marrow cells treated with mRNA for interferon (mRNA-If) obtained from chick cells induced with UV-irradiated Newcastle disease virus was accompanied by the appearance in the blood of the animals of a substance with the properties of interferon, inhibiting the cytopathic effect of vesicular stomatitis virus in chick embryo cells but not in mouse L cells. Chicken interferon was detected in the blood of the experimental animals for 7--10 days after transplantation of mRNA-If-treated cells.
Insights
Researchers transferred mRNA for interferon (mRNA-If) treated bone marrow cells into mice. This resulted in detectable chicken interferon in mouse blood, showing its therapeutic potential.
Area of Science:
- Immunology
- Virology
- Molecular Biology