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[Pediatric inflammatory bowel disease: is it still increasing?]
Ana Fernandes1, Sílvia Bacalhau, José Cabral
1Unidade de Gastrenterologia e Hepatologia Infantil, Hospital de Dona Estefânia, CHLC, Lisboa, Portugal.
Insights
Inflammatory Bowel Disease (IBD) incidence in children is rising, with Crohn's disease (CD) being most common. Diagnosis times are improving, though presentation age remains consistent.
Area of Science:
- Pediatric Gastroenterology
- Chronic Disease Epidemiology
- Inflammatory Bowel Disease (IBD) Research
Context:
- Inflammatory Bowel Disease (IBD), encompassing Crohn's disease (CD), Ulcerative Colitis (UC), and Indeterminate Colitis (IC), is increasingly diagnosed in pediatric populations.
- Global incidence of IBD has shown a significant upward trend over the past five decades, particularly in industrialized nations.
Purpose:
- To characterize the pediatric IBD population diagnosed and followed at Hospital de Dona Estefânia (HDE).
- To analyze trends in IBD diagnosis, clinical presentation, and time to diagnosis in children over a 23-year period (1987-2009).
Summary:
- A retrospective study of 100 pediatric IBD patients revealed a rising incidence, with CD being the most prevalent diagnosis (59%).
- The period 2005-2009 saw the highest number of new cases, averaging 11 per year, compared to 1.5 per year between 1987-1992.
- While the time from symptom onset to diagnosis decreased significantly (from 9 to 4 months), the mean age at diagnosis (10.5 years) and common presenting symptoms (abdominal pain, diarrhea, hematochezia) remained consistent.
Impact:
- Highlights the increasing burden of pediatric IBD, emphasizing the need for early detection and management strategies.
- Provides valuable epidemiological data on pediatric IBD trends, informing public health initiatives and clinical practice guidelines.
- Demonstrates improvements in diagnostic timeliness, potentially leading to better patient outcomes in pediatric IBD.
Introduction:
Crohn's disease (CD), Ulcerative Colitis (UC) and Indeterminate Colitis (IC), commonly known as Inflammatory Bowel Disease (IBD) represent a heterogeneous group of chronic diseases of unknown origin and varying course, diagnosed in pediatric age at 25 to 30% of cases. Epidemiological international studies studies show IBD incidence has increased exponentially in industrialized nations over the last 50 years.
Objectives:
Characterization of the pediatric population diagnosed with IBD, followed at medical consultation in Gastroenterology at Hospital de Dona Estefânia (HDE).
Material And Methods:
Descriptive and retrospective study by consulting the medical files of patients diagnosed with IBD followed between 1987 and 2009 (23 years). Clinical, radiological and histological criteria were used to define IBD. The following variables were studied: sex, family history, race, characterization of IBD, age at diagnosis, time from onset of symptoms to diagnosis and clinical presentation. Four different periods of time were compared: 1987-1992, 1993-1998, 1999-2004 and 2005-2009.
Results:
100 children were included (51 female), of which 59% are CD, 38% UC and 3% IC. Family history of IBD was present in 7 cases, with no sex difference between UC and CD. During the period of time between 2005-2009, it was registered the highest number of new cases (55 total, mean: 11 cases / year) and between 1987-1992 the lowest (9, 1.5 cases / year). Time from onset of symptoms to diagnosis was highly variable, ranging from 9 months (1987-1992) to 4 months (2005-2009). Children's age at the time of diagnosis varied from 14 months to 17 years, with a mean of 10.5 years. The most common symptoms at time of presentation were abdominal pain, diarrhea, and hematochezia.
Conclusion:
IBD are a heterogeneous group of diseases, not always easy to diagnose and difficult to classify as diagnostic criteria are not always uniform. The results show the number of IBD new cases has been rising during the last two decades, mainly CD, with no difference between gender. Time from onset of symptoms to diagnosis has been decreasing although age at time of diagnosis and clinical presentation has showed no difference in the last 20 years.
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