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Histone dosage regulates DNA damage sensitivity in a checkpoint-independent manner by the homologous recombination

Dun Liang1, Sarah Lyn Burkhart, Rakesh Kumar Singh

  • 1Department of Biomedical Sciences, College of Medicine, Florida State University, 1115 West Call Street, Tallahassee, FL 32306-4300, USA.

Nucleic Acids Research
|August 2, 2012
PubMed

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Homologous Recombination

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Homologous Recombination02:31

Homologous Recombination

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage can Stall the Cell Cycle02:36

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