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Updated: May 20, 2026
09:03
Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
Published on: November 23, 2014
Cancer prevention by targeting angiogenesis.
Adriana Albini1, Francesca Tosetti, Vincent W Li
1IRCCS MultiMedica, Science and Technology Pole, Via Fantoli 16/15, Milan 20138, Italy. adriana.albini@ multimedica.it
Nature Reviews. Clinical Oncology
|August 2, 2012
Summary
Angioprevention targets new blood vessel formation to halt early-stage tumors and prevent cancer. This strategy may also prevent chronic inflammatory, autoimmune, and neurodegenerative diseases by controlling angiogenesis.
Area of Science:
- Oncology
- Preventive Medicine
- Vascular Biology
Background:
- Microscopic tumors and dysplastic foci can remain dormant for years in healthy individuals.
- Tumor progression and disease manifestation depend on angiogenesis and inflammation.
- Current anti-cancer therapies are often initiated too late in the disease course.
Purpose of the Study:
- To propose angioprevention as a strategy to prevent tumor growth and progression before clinical manifestation.
- To outline mechanisms and safe clinical strategies for preventive angioprevention.
- To explore the potential of angioprevention beyond cancer for other angiogenesis-dependent chronic disorders.
Main Methods:
- Review of existing literature on angiogenesis inhibitors and chemoprevention.
- Proposal of a risk-stratified clinical angioprevention framework.
- Identification of potential drugs for different levels of preventive angioprevention.
Main Results:
- Angiogenesis is a critical target for preventing tumor dormancy.
- Chemopreventive drugs can inhibit angiogenesis in the tumor microenvironment.
- Preventive angioprevention could maintain neoplasia in a dormant state, preventing cancer development.
Conclusions:
- Angioprevention offers a novel approach to cancer prevention by targeting angiogenesis early.
- This strategy could potentially prevent a range of chronic diseases including inflammatory, autoimmune, ocular, and neurodegenerative disorders.
- Further research is needed to establish safe and effective clinical angioprevention protocols.
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