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Updated: May 12, 2026

Monitoring Dynamic Changes In Mitochondrial Calcium Levels During Apoptosis Using A Genetically Encoded Calcium Sensor
Published on: April 1, 2011
Mitochondria as sensors and regulators of calcium signalling
Rosario Rizzuto1, Diego De Stefani, Anna Raffaello
1Department of Biomedical Sciences, University of Padua and CNR Neuroscience Institute, Via G. Colombo 3, 35131 Padua, Italy. rosario.rizzuto@unipd.it
Abstract:
During the past two decades calcium (Ca(2+)) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca(2+) uptake was shown to control intracellular Ca(2+) signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytosolic Ca(2+) levels and regulating mitochondrial effectors. Recently, the identity of mitochondrial Ca(2+) transporters has been revealed, opening new perspectives for investigation and molecular intervention.
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