Related Experiment Video

Updated: May 20, 2026

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

[Echocardiographic associations with renal function in hypertensive individuals treated at primary care level]

Fernando Alberto Costa Cardoso da Silva1, Vinícius José da Silva Nina, Alcione Miranda Dos Santos

  • 1Hospital Universitário, Universidade Federal do Maranhão, São Luis, MA, Brazil.

Jornal Brasileiro De Nefrologia
|August 2, 2012
PubMed

Insights

Microalbuminuria and reduced glomerular filtration rate in hypertensive patients are linked to detrimental changes in left ventricular structure and diastolic function, including increased wall thickness and mass.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Hypertension is associated with cardiac complications.
  • Microalbuminuria (MA) and impaired glomerular filtration rate (GFR) are indicators of cardiovascular risk.
  • These factors can lead to structural and functional changes in the left ventricle (LV).

Purpose of the Study:

  • To investigate the correlation between MA and GFR with LV parameters.
  • To assess changes in LV geometry and function using echocardiography in hypertensive patients.

Main Methods:

  • Cross-sectional study of 220 hypertensive patients (age > 18).
  • Assessment of sociodemographic data, 24-hour urine MA, GFR, and echocardiographic LV parameters.
  • Patients grouped based on MA and GFR levels.

Main Results:

  • Hypertensive patients with MA showed increased LV wall thickness, LV mass indexed for body surface area (BSA), and relative wall thickness (RWT).
  • These patients also exhibited altered diastolic function, indicated by lower E' waves and higher E/e' ratio.
  • Reduced GFR (< 60 mL/min/1.73 m²) was similarly associated with increased LV wall thickness, LV mass, and impaired diastolic function.
  • Left ventricular concentric hypertrophy was significantly related to MA.

Conclusions:

  • MA is significantly associated with increased LV wall thickness, LV mass, and diastolic dysfunction.
  • Left ventricular concentric hypertrophy is linked to MA in hypertensive individuals.
  • GFR is also associated with cardiac structural changes and diastolic dysfunction, highlighting its clinical relevance.
Abstract

More Related Videos

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches06:51

Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches

Published on: September 5, 2025

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

Related Concept Videos

Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...