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Increased Body Temperature

Increased Body Temperature

A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.

Homeostatic Imbalances in Body Temperature

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...

Types of Fever

Types of Fever

Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:

Hyperthyroidism II: Pathophysiology

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

Hyperthyroidism I: Introduction

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

Methods of reducing fever

Methods of reducing fever

The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:

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Related Experiment Video

Updated: May 20, 2026

Protocol for Long Duration Whole Body Hyperthermia in Mice

Protocol for Long Duration Whole Body Hyperthermia in Mice

Published on: August 25, 2012

Malignant hyperthermia.

Oliver Bandschapp¹, Thierry Girard

¹Department of Anaesthesia and Intensive Care Medicine, University of Basel, Basel, Switzerland. bandschappo@uhbs.ch

Swiss Medical Weekly

|August 2, 2012

Summary

This summary is machine-generated.

Malignant hyperthermia (MH) is a genetic myopathy often triggered by anesthesia. Genetic testing identifies mutations in over 70% of MH families, but screening remains challenging.

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A Preclinical Model of Exertional Heat Stroke in Mice

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Area of Science:

Anesthesiology
Genetics
Pharmacology

Background:

Malignant hyperthermia (MH) is a life-threatening pharmacogenetic disorder of skeletal muscle.
It is typically triggered by volatile anesthetics and depolarizing muscle relaxants.
Clinical diagnosis can be challenging due to variable symptoms.

Purpose of the Study:

To review the current understanding of malignant hyperthermia.
To discuss diagnostic challenges and genetic associations.
To highlight the importance of prompt management.

Main Methods:

Review of existing literature on malignant hyperthermia.
Analysis of molecular genetic findings related to MH.
Discussion of clinical presentation and management strategies.

Main Results:

Mutations in the skeletal muscle ryanodine receptor gene are found in over 70% of MH families.
Current diagnostic methods, including muscle biopsy and genetic testing, have limitations.
MH susceptibility can be triggered by non-anesthetic agents and exertional heat stroke.

Conclusions:

Early recognition and treatment of MH are critical for patient survival.
Genetic testing has advanced MH diagnosis but is not a universal screening tool.
Further research is needed to understand MH prevalence and improve diagnostic approaches.