Central effects of octopamine administered into the lateral ventricle of rats

Central effects of octopamine administered into the lateral ventricle of rats. Acta physiol. pol., 1979, 30 (4): 445--453. Octopamine (100, 250 and 500 micrograms/rat i.v.c.) exerted a stimulating effect on the central nervous system in rats, which was evidenced by increased spontaneous and basal motor activity, increased exploratory activity in the free-field test, and also increased motor activity in reserpinised rats pretreated with alpha-MT or nialamide. Octopamine decreased the body temperature and prolonged the duration of hexobarbital-induced sleep, and increased amphetamine-induced hyperactivity. Locomotor agitation after octopamine injection was inhibited by phenoxybenzamine and yohimbine in a dose of 10 mg/kg i.p.