Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

OKT3 encephalopathy.

A E Coleman1, D J Norman

  • 1Department of Neurology, Oregon Health Sciences University, Portland 97201.

Annals of Neurology
|December 1, 1990
PubMed
Summary
This summary is machine-generated.

OKT3 therapy for kidney transplant immunosuppression caused brain swelling, leading to obtundation and quadriparesis. Symptoms resolved with supportive care and discontinuing OKT3 (muromonab-CD3).

Related Experiment Videos

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effect of excipients on the oral absorption of pimobendan in healthy dogs.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2025
Same author

Agreement of echocardiographic and catheterization-based methods of transpulmonary pressure gradient measurement in dogs.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024
Same author

Comparative transcatheter occlusion of patent ductus arteriosus: multicenter collaborative study across pediatric and veterinary cardiology centers.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024
Same author

Comparison of manual compression, Z-stitch, and suture-mediated vascular closure device techniques in dogs undergoing percutaneous transvenous intervention.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2023
Same author

Single- and multiple-dose pharmacokinetics of sotalol hydrochloride in healthy cats.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2023
Same author

Transcatheter closure of patent ductus arteriosus in 11 dogs and one cat after incomplete or aborted surgical ligation.

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2022

Area of Science:

  • Nephrology
  • Neuroscience
  • Immunology

Background:

  • The use of OKT3 (muromonab-CD3) as induction immunosuppression is standard in renal transplantation.
  • Monitoring for adverse neurological effects is crucial in post-transplant care.

Observation:

  • A renal transplant recipient receiving OKT3 induction therapy developed obtundation and quadriparesis.
  • Computed tomographic (CT) scans revealed evidence of cerebral edema.

Findings:

  • The patient's neurological deficits and brain edema resolved within 3 days.
  • Cessation of OKT3 therapy and supportive management were key to recovery.

Implications:

  • This case highlights a potential association between OKT3 therapy and reversible brain edema in transplant patients.
  • Clinicians should consider neurological monitoring and prompt OKT3 withdrawal if adverse effects occur.