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Diabetic angiopathy and angiogenic defects
Ling Xu1, Keizo Kanasaki, Munehiro Kitada
1Division of Diabetology & Endocrinology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan. kkanasak@kanazawa-med.ac.jp.
Fibrogenesis & Tissue Repair
|August 3, 2012
Summary
Diabetes complications involve abnormal blood vessel growth (angiogenesis). This review examines angiogenesis in diabetic vascular issues, exploring its therapeutic potential and links to glucose metabolism defects in conditions like cancer.
Area of Science:
- Endocrinology
- Vascular Biology
- Oncology
Background:
- Diabetes mellitus is a global health crisis.
- Diabetic complications frequently involve vascular disease (angiopathy).
- Abnormal angiogenesis is a hallmark of diabetic angiopathy.
Purpose of the Study:
- To review angiogenesis abnormalities in diabetic complications.
- To evaluate angiogenesis as a therapeutic target for diabetic vascular disease.
- To explore the link between glucose metabolism and angiogenesis in atypical diabetic conditions like cancer.
Main Methods:
- Literature review of studies on diabetes, angiogenesis, and vascular complications.
- Analysis of the dual role (beneficial and detrimental) of angiogenesis in diabetic settings.
- Examination of molecular mechanisms connecting glucose metabolism defects to aberrant angiogenesis.
Main Results:
- Abnormal angiogenesis contributes significantly to diabetic vascular complications.
- Targeting angiogenesis presents both opportunities and challenges for therapy.
- Altered glucose metabolism is implicated in angiogenesis dysregulation in cancers associated with diabetes.
Conclusions:
- Understanding angiogenesis is crucial for managing diabetic vascular complications.
- Therapeutic strategies targeting angiogenesis require careful consideration of context.
- Further research into glucose metabolism's role in diabetic angiogenesis is warranted for novel treatments.
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