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Related Experiment Video

Updated: May 19, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Carotid atherosclerosis and 10-year changes in cognitive function.

Wenjun Zhong¹, Karen J Cruickshanks, Carla R Schubert

¹University of Wisconsin-Madison, 1036 WARF, 610 Walnut Street, WI 53726, USA. zhongwenjun80@gmail.com

Atherosclerosis

|August 3, 2012

Summary

This summary is machine-generated.

Carotid intima-media thickness (IMT), a marker of atherosclerosis, is linked to increased cognitive decline risk and poorer executive function over ten years. Plaque buildup showed no significant association with cognitive impairment.

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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

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Published on: August 12, 2025

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Last Updated: May 19, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

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A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

A Magnetic Resonance Imaging-based Computational Protocol for Analysis of Plaque Morphology and Hemodynamics in Patients with Carotid Artery Stenosis

Published on: August 12, 2025

Area of Science:

Neurology
Cardiovascular Science
Gerontology

Background:

Carotid atherosclerosis is increasingly implicated in age-related cognitive decline.
Understanding the link between vascular health and brain function is crucial for aging populations.

Purpose of the Study:

To investigate the association between carotid atherosclerosis markers (IMT and plaque) and cognitive function over a 10-year period.
To determine if carotid intima-media thickness (IMT) predicts incident cognitive impairment and cognitive test performance.

Main Methods:

Longitudinal study (Epidemiology of Hearing Loss Study) of 1651 participants (mean age 66.8 years).
Carotid intima-media thickness (IMT) and plaque measured via ultrasound; cognitive function assessed using Mini-Mental State Examination (MMSE) and additional tests.
Cognitive impairment defined as MMSE score <24 or physician-diagnosed dementia.

Main Results:

Increased carotid IMT was significantly associated with a higher incidence of cognitive impairment (HR: 1.09 per 0.1 mm increase, p=0.02).
Larger IMT correlated with slower performance on the Trail-Making Test-part B (2.3s longer per 0.1 mm increase, p=0.02).
Carotid plaque was not significantly associated with cognitive impairment or performance on cognitive tests.

Conclusions:

Carotid intima-media thickness (IMT) is a predictor of cognitive impairment and executive function decline over a decade.
These findings highlight the importance of vascular health in maintaining cognitive function in older adults.