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Updated: May 19, 2026

Inducing Apical Periodontitis in Mice

Inducing Apical Periodontitis in Mice

Published on: August 6, 2019

Periapical actinomycosis.

Sanjay P Pasupathy¹, Dhanavel Chakravarthy, Sumathy Chanmougananda

¹Department of Oral & Maxillofacial Surgery, Sri Manakula Vinayaka Medical College, Pondicherry, India.

BMJ Case Reports

|August 3, 2012

Summary

Periapical actinomycosis, a rare infection of the jaw, can mimic other conditions. Early histopathological examination of surgical tissue aids in diagnosing this challenging condition for effective antibiotic treatment.

Area of Science:

Oral and Maxillofacial Surgery
Infectious Diseases
Pathology

Background:

Actinomycosis is a rare, chronic bacterial infection caused by Actinomyces species.
It presents with abscesses, fibrosis, and draining fistulas, often containing sulfur granules.
Diagnosis is challenging due to non-specific clinical features and varied presentations.

Observation:

Periapical actinomycosis is an exceptionally rare manifestation in the maxillofacial region.
This case involved a persistent, recurrent draining fistula in the periapical region of endodontically treated teeth.
The condition was incidentally discovered during histopathological examination.

Findings:

Histopathology is crucial for identifying Actinomycosis, especially in periapical lesions.

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The study discusses potential routes of Actinomyces entry into the periapical tissues.

Prompt histopathological analysis of surgical specimens can lead to accurate diagnosis.

Implications:

Sending periapical surgical tissues for histopathology is vital for diagnosing rare infections like actinomycosis.
Accurate diagnosis facilitates appropriate antibiotic therapy, leading to improved patient outcomes.
This highlights the importance of considering actinomycosis in persistent periapical inflammatory conditions.