Related Experiment Video
Updated: May 19, 2026

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
Published on: April 23, 2016
Finding the will and the way of ERAD substrate retrotranslocation
Randolph Y Hampton1, Thomas Sommer
1UCSD Division of Biological Sciences, Section of Cell and Developmental Biology, La Jolla, CA, United States. rhampton@ucsd.edu
Abstract:
ER-associated degradation (ERAD) is a mechanism by which numerous ER-localized proteins are targeted for cytosolic degradation by the ubiquitin-proteasome system. A surprising and still-cryptic requirement of this process is the energy dependent retrotranslocation of both lumenal and membrane-embedded ER proteins into the cytosol for ongoing ubiquitination and proteasomal destruction. The current understanding, results, and open questions are discussed below for this intriguing and critical process of ERAD.
More Related Videos
11:28Designing, Packaging, and Delivery of High Titer CRISPR Retro and Lentiviruses via Stereotaxic Injection
Published on: May 23, 2016
11:12Determination of the Optimal Chromosomal Location(s) for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
Published on: September 11, 2017
Related Concept Videos
Export of Misfolded Proteins out of the ER
LTR Retrotransposons
The internal coding region of LTR retrotransposons and their mechanism of transposition closely resembles a...
Non-LTR Retrotransposons
Retrovirus Life Cycles
Retroviruses
Mechanisms of Retrovirus-induced Cancers