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Intermittent Binge-Intake Model in Mice
Published on: January 10, 2025
Baclofen reduces binge eating in a double-blind, placebo-controlled, crossover study
Rebecca L Corwin1, Jarol Boan, Kathryn F Peters
1Department of Nutritional Sciences, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania 16801, USA. rxc13@psu.edu
Behavioural Pharmacology
|August 3, 2012
Summary
Baclofen significantly reduced binge eating frequency in a double-blind study, confirming previous findings. While effective, it may slightly increase depression symptoms and cause side effects like tiredness.
Area of Science:
- Clinical Psychology
- Psychopharmacology
- Neuroscience
Background:
- Baclofen shows potential for substance use disorders.
- Previous open-label trials indicated baclofen reduced binge eating frequency.
Purpose of the Study:
- To further assess baclofen's efficacy in treating binge eating.
- To evaluate baclofen's effects on binge frequency, severity, and craving in a placebo-controlled setting.
Main Methods:
- A placebo-controlled, double-blind, crossover study involving 12 individuals with binge eating.
- Participants underwent a run-in period, a 48-day placebo phase, and a 48-day baclofen phase (up to 60 mg/day).
- Data collected via daily binge diaries, Binge Eating Scale (BES), Food Craving Inventory-II (FCI-II), and Hospital Anxiety and Depression Scale (HADS).
Main Results:
- Baclofen significantly decreased binge eating frequency compared to placebo and run-in periods (P<0.05).
- Both placebo and baclofen phases showed significant reductions in binge severity (BES) and craving (FCI-II), indicating placebo effects.
- Baclofen was associated with slight but significant increases in depression symptomatology (HADS).
- Common side effects included tiredness, fatigue, and upset stomach.
Conclusions:
- Baclofen may serve as a beneficial treatment for binge eating in select patient populations.
- The study confirms baclofen's efficacy in reducing binge frequency.
- Further research is warranted to explore baclofen's long-term effects and optimal dosing, considering potential mood side effects.
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