Introduction to stereology

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Updated: May 19, 2026

Knowing What Counts: Unbiased Stereology in the Non-human Primate Brain
11:25

Knowing What Counts: Unbiased Stereology in the Non-human Primate Brain

Published on: May 14, 2009

Mark J West

    Cold Spring Harbor Protocols
    |August 3, 2012
    PubMed

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    On the basis of mirror symmetry, stereoisomers of an organic molecule can be further classified into diastereomers and enantiomers. Diastereomers are stereoisomers that are not mirror images of each other. Substituted alkenes, such as the cis and trans isomers of 2-butene, are diastereomers, as these molecules exhibit different spatial orientations of their constituent atoms, are not mirror images of each other, and do not interconvert. Here, the interconversion is suppressed due to restricted...
    Stereoisomerism of Cyclic Compounds02:33

    Stereoisomerism of Cyclic Compounds

    In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
    Gauss's Law: Spherical Symmetry01:26

    Gauss's Law: Spherical Symmetry

    A charge distribution has spherical symmetry if the density of charge depends only on the distance from a point in space and not on the direction. In other words, if the system is rotated, it doesn't look different. For instance, if a sphere of radius R is uniformly charged with charge density ρ0, then the distribution has spherical symmetry. On the other hand, if a sphere of radius R is charged so that the top half of the sphere has a uniform charge density ρ1 and the bottom half has a uniform...
    Gauss's Law: Cylindrical Symmetry01:20

    Gauss's Law: Cylindrical Symmetry

    A charge distribution has cylindrical symmetry if the charge density depends only upon the distance from the axis of the cylinder and does not vary along the axis or with the direction about the axis. In other words, if a system varies if it is rotated around the axis or shifted along the axis, it does not have cylindrical symmetry. In real systems, we do not have infinite cylinders; however, if the cylindrical object is considerably longer than the radius from it that we are interested in,...