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Updated: May 19, 2026
Necropsy-based Wild Fish Health Assessment
Published on: September 11, 2018
Clinical and histopathological features of a suspected case of fish-eye disease
Hiroko Tateno1, Makoto Taomoto, Nobuo Jo
1Department of Ophthalmology, Kansai Medical University, 2-3-1 Shinmachi, Hirakata, Osaka 573-1191, Japan. tatenoh@hirakata.kmu.ac.jp
Purpose:
To report the clinical and histopathological features of a suspected case of fish-eye disease.
Case:
A 57-year-old man presented with blurred vision. The best corrected visual acuity was 0.8 OD and 1.0 OS. The patient had no family history of cloudy cornea. Slit-lamp examination revealed massive bilateral diffuse corneal clouding. Because of progressive corneal clouding during the previous 3 years, we performed penetrating keratoplasty and cataract surgery. He had a low-plasma, high-density lipoprotein (HDL) concentration. Histopathologically, numerous small vacuoles were dispersed, especially in the anterior corneal stroma. An electron microscope revealed distinct 0.2-3.0-μm lipid vacuoles with a conserved stromal structure.
Conclusion:
We suspected a case of sporadic fish-eye disease in a Japanese patient. Lipid deposition needs to be considered as a cause of diffuse corneal opacity.
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