Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Hypoxia01:23

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Oxygen Transport in the Blood01:27

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Oxygen Requirements and Growth Patterns01:29

Oxygen Requirements and Growth Patterns

Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospective exploratory pilot study of 18 F-FMISO PET/CT for assessing tumor hypoxia in soft tissue sarcomas.

Cancer imaging : the official publication of the International Cancer Imaging Society·2026
Same author

Integrated Single-Cell and Spatial Profiling of MMP Gene Expression in Colorectal Cancer.

bioRxiv : the preprint server for biology·2026
Same author

The effect of walnut consumption on the peripheral blood mononuclear cell transcriptome.

Genes & nutrition·2026
Same author

Transcriptomic and Proteomics Analysis of a Lipid-Loaded HepaRG Model for Steatosis Reveals Altered Regulation in Lipid and Xenobiotic Metabolism.

Current drug metabolism·2025
Same author

Evaluation of UCP1162, a potent propargyl-linked inhibitor of dihydrofolate reductase with potential application to cancer and autoimmune disease.

Biochemical pharmacology·2024
Same author

An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis.

The Journal of experimental medicine·2024

Related Experiment Video

Updated: May 19, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

Hyperbaric oxygen preconditioning protects skin from UV-A damage.

Ashley M Fuller1, Charles Giardina, Lawrence E Hightower

  • 1Department of Molecular and Cell Biology, University of Connecticut, 91 North Eagleville Road, U3125, Storrs, CT 06269, USA.

Cell Stress & Chaperones
|August 3, 2012
PubMed
Summary

Hyperbaric oxygen therapy (HBOT) pretreatment protects skin from UV-A damage by reducing cell death and improving elasticity. This therapy also shows systemic benefits, offering potential for broader tissue protection.

More Related Videos

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Related Experiment Videos

Last Updated: May 19, 2026

Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
10:05

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Area of Science:

  • Dermatology
  • Biomedical Engineering
  • Oxidative Stress Research

Background:

  • Hyperbaric oxygen therapy (HBOT) is clinically used for conditions like diabetic foot ulcers and CO poisoning.
  • HBOT mobilizes cellular antioxidant defenses, suggesting potential for tissue protection against oxidative damage.
  • UV-A radiation induces oxidative stress and damage in cutaneous tissues.

Purpose of the Study:

  • To evaluate the protective effects of hyperbaric oxygen (HBO) preconditioning on skin tissue against UV-A-induced oxidative damage.
  • To assess HBO's impact on UV-A-induced apoptosis, proliferation, skin creasing, and elasticity.
  • To investigate potential systemic effects of HBO pretreatment on liver caspase-3 activity.

Main Methods:

  • Hairless SKH1-E mice were divided into three groups, exposed to UV-A radiation for 22 weeks.
  • Two groups received HBO pretreatment (2 or 4 times/week) prior to UV-A exposure.
  • Skin tissue and liver samples were analyzed for apoptosis, proliferation, morphometric changes, elasticity, and caspase-3 activity.

Main Results:

  • UV-A exposure increased skin apoptosis and proliferation, indicating damage and repair.
  • HBO pretreatment significantly reduced UV-A-induced apoptosis and proliferation.
  • HBO pretreatment prevented UV-A-induced skin creasing and improved skin elasticity, with greater effect at 4x/week.
  • Systemic effects included reduced liver caspase-3 activity in HBO-treated groups.

Conclusions:

  • HBO pretreatment provides significant protection to cutaneous tissue against UV-A-induced oxidative damage.
  • HBO pretreatment mitigates UV-A-induced skin aging markers like creasing and loss of elasticity.
  • HBO demonstrates systemic protective effects, suggesting potential applications for other tissues facing oxidative challenges.