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Updated: May 19, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
Published on: June 13, 2014
Tyrosine kinases EnAbling adaptor molecules for chemokine-induced Rap1 activation in T cells
Laurent P Malherbe1, Demin Wang
1Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA. laurent.malherbe@bcw.edu
Abstract:
Chemokines regulate T cell trafficking into secondary lymphoid organs and migration across endothelial cells in response to inflammatory signals. The small guanosine triphosphatase Rap1 is a critical regulator of chemokine signaling in T cells, but how chemokines activate Rap1 has been unclear. A study showed that Abl family tyrosine kinases were essential for chemokine-induced Rap1 activation, T cell polarization, and migration. Abl family kinases promoted Rap1 activation by phosphorylating the adaptor protein human enhancer of filamentation 1 (HEF1), thus establishing a critical Abl-HEF1-Rap1 signaling axis for chemokine-induced T cell migration.
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