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Updated: Dec 26, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

DNA viruses and the cellular DNA-damage response.

Andrew S Turnell¹, Roger J Grand¹

¹School of Cancer Sciences, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.

The Journal of General Virology

|August 3, 2012

Summary

Viruses manipulate host DNA damage response pathways to replicate. This review examines how DNA viruses manage ATM, ATR, and DNA-PK pathways for their life cycles.

Area of Science:

Virology
Molecular Biology
Cellular Biology

Background:

Host-cell factors influence viral replication, with some promoting it and others inhibiting it.
A complex interplay exists between viral infections and host-cell DNA damage response and repair pathways.
Viruses can modulate these pathways to favor their own replication.

Purpose of the Study:

To review how DNA viruses manage key DNA damage-response pathways.
To explore the roles of ATM, ATR, and DNA-PK in viral replication.
To understand virus-host interactions at the molecular level.

Main Methods:

Review of existing literature on DNA virus interactions with host DNA damage pathways.
Focus on the roles of ATM, ATR, and DNA-PK signaling.

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Last Updated: Dec 26, 2025

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

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Visualization of DNA Repair Proteins Interaction by Immunofluorescence

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Published on: June 8, 2018

Analysis of how viruses manipulate these pathways.

Main Results:

Viruses selectively activate or repress components of DNA damage pathways.
Some viruses, like simian virus 40, require active repair pathways.
Other viruses, like adenovirus, inactivate specific pathways.

Conclusions:

DNA viruses have evolved sophisticated strategies to manage host DNA damage responses.
Understanding these interactions is crucial for deciphering virus life cycles.
Further research is needed to fully elucidate the molecular mechanisms involved.