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The effect of soy protein beverages on serum cell adhesion molecule concentrations in prehypertensive/stage 1

Michelle Dettmer1, D Lee Alekel, Joanne A Lasrado

  • 1Department of Food Science & Human Nutrition, Nutrition & Wellness Research Center, Research Park, Ames, Iowa, USA.

Journal of the American College of Nutrition
|August 3, 2012
PubMed

Insights

Neither cow's milk nor soy beverages lowered cell adhesion molecules in individuals with prehypertension or stage 1 hypertension. This suggests neither drink reduces atherosclerotic cardiovascular disease risk by improving these markers.

Area of Science:

  • Cardiovascular Disease Research
  • Nutritional Science
  • Endocrinology

Background:

  • Prehypertension and hypertension increase atherosclerotic cardiovascular disease (CVD) risk due to endothelial dysfunction and elevated cell adhesion molecules (CAMs).
  • Soy protein and isoflavones may offer cardiovascular benefits by favorably altering CVD risk factors.

Purpose of the Study:

  • To investigate if cow's milk, whole soy bean (WSB) beverage, or soy protein isolate (SPI) beverage consumption impacts soluble CAM concentrations.
  • To assess the potential of these beverages in reducing CVD risk by modulating CAM levels in prehypertensive/stage 1 hypertensive individuals.

Main Methods:

  • A randomized controlled trial involving 60 men and 8 women with prehypertension/stage 1 hypertension over 8 weeks.
  • Participants consumed either cow's milk (600 mL/d), SPI beverage (840 mL/d; 30.1 mg isoflavones/d), or WSB beverage (840 mL/d; 91.4 mg isoflavones/d).
  • Soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), and endothelial-leukocyte adhesion molecule-1 (E-selectin) were measured at baseline and week 8.

Main Results:

  • No significant alterations in soluble CAM concentrations were observed across treatment groups or between prehypertensive and hypertensive participants.
  • A significant gender interaction was found for ICAM-1, with men exhibiting higher baseline and week 8 concentrations than women.
  • No significant treatment effect was noted for VCAM-1 or E-selectin, though a trend was observed for E-selectin.

Conclusions:

  • Eight weeks of consuming cow's milk or soy beverages did not alter soluble CAM concentrations in individuals with prehypertension/stage 1 hypertension.
  • These findings suggest that neither beverage effectively reduces atherosclerotic CVD risk through improvements in circulating CAM concentrations in this population.
Abstract

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