Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Cemiplimab Plus Chemotherapy Versus Chemotherapy in Advanced NSCLC: 5-year Results From Phase 3 EMPOWER-Lung 3 Part 2 Trial.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer·2026

Same author

Performance of Mandibular Advancement Devices When Opening the Mouth.

Annals of biomedical engineering·2026

Same author

Health insurance type moderates the association between substance use disorders and cardiovascular multimorbidity among U.S. adults - Results from the 2023 National Survey on Drug use and Health.

Substance abuse treatment, prevention, and policy·2026

Same author

The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.

Behavior genetics·2026

Same author

Transforming wearable data into personal health insights using large language model agents.

Nature communications·2026

Same author

Influence of Surgical and Prosthetic Factors on Peri-Implant Health or Disease. Clinical Recommendations From a Spanish Society of Periodontology (SEPA) Expert Consensus.

Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]·2026

Search research articles

Related Experiment Video

Updated: May 19, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

White matter heritability using diffusion tensor imaging in neonatal brains.

Xiujuan Geng¹, Elizabeth C Prom-Wormley, Javier Perez

¹Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.

Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies

|August 4, 2012

Summary

This summary is machine-generated.

White matter development in infants is significantly influenced by genetics, with individual differences in brain structure being heritable. These genetic effects vary across brain regions and are modulated by maturation, offering insights into neurodevelopmental disorders.

More Related Videos

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Related Experiment Videos

Last Updated: May 19, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

DTI of the Visual Pathway - White Matter Tracts and Cerebral Lesions

Published on: August 26, 2014

Area of Science:

Neuroscience
Genetics
Developmental Biology

Background:

Understanding neurodevelopmental disorders requires knowledge of genetic and environmental influences on early brain development.
White matter development is crucial for cognitive functions and is shaped by both genetic and environmental factors.

Purpose of the Study:

To estimate the genetic and environmental contributions to white matter microstructure in neonates.
To investigate regional variations in heritability and environmental effects on diffusion parameters.
To explore the relationship between maturation status and genetic influences on white matter development.

Main Methods:

Utilized diffusion tensor imaging (DTI) on 173 neonatal twin subjects.
Applied a variance components model to estimate genetic and environmental influences on diffusion parameters (fractional anisotropy, radial diffusivity, axial diffusivity).
Analyzed data across 98 regions of interest (ROIs) and examined correlations between heritability and diffusion parameters.

Main Results:

Individual differences in overall white matter microstructure are heritable in neonates, with higher estimates than in adults.
Genetic and environmental influences varied significantly across different white matter regions.
Positive correlations between radial diffusivity heritability and radial diffusivity values suggest maturation modulates genetic variation.

Conclusions:

Neonatal white matter development is substantially heritable, with regional differences influenced by maturation.
Environmental effects are present in specific white matter regions.
Multivariate modeling may enhance understanding of maturation and its interplay with genetic and environmental factors in brain development.