Imaging and cognitive genetics: the Norwegian Cognitive NeuroGenetics sample

Area of Science:

• Neuroscience
• Genetics
• Cognitive Science

Background:

• The Norwegian Cognitive NeuroGenetics sample (NCNG) was established in 2003 to study cognitive aging and genetic risk factors.
• Initial focus on aging effects and candidate genes evolved to encompass broader cognitive genetics and neuroimaging.

Purpose of the Study:

• To comprehensively study the genetics of cognitive and brain function.
• To provide researchers with information for multi-sample data analyses.

Main Methods:

• Longitudinal and cross-sectional designs incorporating cognitive and MRI-based data.
• Genome-wide association (GWA) studies initiated in 2009.
• Large-scale use of experimental cognitive tasks focusing on attention and working memory in a genetically homogenous sample.

Main Results:

• The NCNG now covers the adult lifespan with high-dimensional imaging and cognitive data.
• The sample size ranges from 300-700 participants for specific tasks.
• Data is utilized in numerous GWA studies and international consortia.

Conclusions:

• The NCNG is a valuable, unique resource for cognitive genetics and neuroimaging research.
• Facilitates collaborative research through data sharing and multi-sample analyses.