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Updated: May 19, 2026

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

[Bacterial meningitis. A rare cause].

Sílvia Bacalhau¹, Maria Manuel Zarcos, Teresa Rezende

¹Serviço de Pediatria, Hospital Santo André, Leiria, Portugal.

Acta Medica Portuguesa

|August 4, 2012

Summary

This summary is machine-generated.

Group A Streptococcus meningitis is rare but increasing. A healthy child recovered fully after prompt antibiotic treatment for this invasive bacterial infection, highlighting the importance of early diagnosis and intervention.

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Area of Science:

Pediatrics
Infectious Diseases
Microbiology

Background:

Meningitis is an uncommon manifestation of invasive Streptococcus pyogenes infection.
Group A Streptococcus (GAS) invasive infections are reportedly increasing.
Prompt recognition and treatment are crucial for managing GAS meningitis.

Observation:

A previously healthy four-year-old girl presented with high fever, vomiting, and stiff neck, indicative of meningitis.
Cerebrospinal fluid analysis confirmed bacterial meningitis, with Streptococcus pyogenes identified as the causative agent.
The patient received a combination of ceftriaxone and clindamycin for 15 days.

Findings:

The child demonstrated a complete clinical recovery without neurological or hearing deficits.
Leukocytosis, thrombocytosis, and elevated C-reactive protein supported the diagnosis of bacterial infection.
Cultures confirmed Streptococcus pyogenes in the cerebrospinal fluid.

Implications:

This case underscores the potential for severe outcomes, including fatality or sequelae, from GAS meningitis, even in healthy children.
Early diagnosis and appropriate antibiotic therapy are critical for favorable outcomes in invasive Streptococcus pyogenes infections.
Continued surveillance for invasive GAS infections is warranted due to the rising incidence.