[Histiocytic necrotizing lymphadenitis: (Kukuchi-Fujimoto disease): a diagnostic challenge]

Area of Science:

• Pathology
• Immunology
• Rheumatology

Background:

• Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare, benign, and self-limiting disorder of unknown cause.
• It primarily affects young women, presenting with fever and lymphadenopathy, typically in the neck.

Observation:

• A 24-year-old woman presented with persistent cervical lymphadenopathy and fever.
• Diagnostic evaluation included an excisional biopsy of the affected lymph node tissue.

Findings:

• Histopathological examination of the lymph node tissue revealed characteristic findings of KFD.
• Immunohistochemical analysis further supported the diagnosis, differentiating it from other conditions.

Implications:

• Accurate diagnosis of KFD is crucial for appropriate management, distinguishing it from diseases with different clinical courses and treatment requirements.
• This case underscores the importance of histopathological and immunohistochemical analysis in diagnosing rare conditions like KFD.