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Related Experiment Video

Updated: May 19, 2026

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
07:51

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method

Published on: May 21, 2018

[Overlap syndrome].

Joana Parente1, Palmira Mathurdas, Luísa Wandschneider

  • 1Serviços de Dermatologia e de Medicina Interna 2, Hospital Distrital de Santarém, Santarém, Portugal.

Acta Medica Portuguesa
|August 4, 2012
PubMed
Summary

Overlap syndromes, where patients have multiple autoimmune diseases, are rare. This case highlights the scleroderma-polymyositis overlap as a distinct clinical entity within autoimmune disease spectrum.

Area of Science:

  • Rheumatology
  • Immunology
  • Internal Medicine

Background:

  • Overlap syndromes involve patients presenting with two or more autoimmune diseases concurrently.
  • The specific overlap between scleroderma and polymyositis is infrequently observed in clinical practice.

Observation:

  • A rare case of a 58-year-old woman with overlapping scleroderma and polymyositis is presented.
  • The patient's clinical presentation, therapeutic response, and disease progression were meticulously documented.

Findings:

  • The distinct clinical features and disease course support the classification of this overlap syndrome as a unique entity.
  • Analysis of the case suggests this specific combination represents a definable condition within the broader spectrum of autoimmune disorders.

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Last Updated: May 19, 2026

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
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Published on: May 21, 2018

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Published on: October 27, 2023

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Published on: March 21, 2019

Implications:

  • Recognizing this scleroderma-polymyositis overlap as a distinct entity can refine diagnostic approaches.
  • Understanding its unique characteristics may lead to more targeted and effective therapeutic strategies for affected patients.
  • This case contributes to the growing body of evidence defining complex autoimmune presentations.