Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Serotonin antagonists and vascular protection.

¹Department of Medicine, St. Vincent's Hospital, Fitzroy, Australia.

Cardiovascular Drugs and Therapy

|January 1, 1990

Summary

Ketanserin may reduce thrombotic events in intermittent claudication patients, but its use is complicated by dangerous interactions with potassium-losing diuretics. Further research is needed to explore ketanserin

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neuropsychology consultation to identify learning disorders in children and adolescents: a proposal based on lessons learned during the COVID-19 pandemic.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence·2022

Same author

What is a processing speed weakness? Importance of cognitive ability when defining processing speed in a child psychiatric population.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence·2021

Same author

Absence of evidence for increase in risk for autism or attention-deficit hyperactivity disorder following antidepressant exposure during pregnancy: a replication study.

Translational psychiatry·2016

Same author

Prenatal antidepressant exposure is associated with risk for attention-deficit hyperactivity disorder but not autism spectrum disorder in a large health system.

Molecular psychiatry·2014

Same author

Executive functioning in high-IQ adults with ADHD.

Psychological medicine·2010

Same author

Neurocognitive impairment in unaffected siblings of youth with bipolar disorder.

Psychological medicine·2008

Area of Science:

Pharmacology
Cardiovascular Medicine
Thrombosis Research

Background:

Serotonin release from platelets plays a role in platelet aggregation, arterial thrombosis, and spasm.
The 5HT2 receptor mediates these effects and is antagonized by ketanserin.

Purpose of the Study:

To evaluate the efficacy of ketanserin in reducing atherosclerotic complications (myocardial infarction, stroke) in patients with intermittent claudication.
To investigate potential adverse interactions of ketanserin with other medications.

Main Methods:

A randomized controlled trial (PACK study) comparing ketanserin with placebo.
Intention-to-treat and on-treatment analyses were performed.
Patients taking potassium-losing diuretics were a focus of safety analysis.

Main Results:

An unexpected, fatal interaction between ketanserin and potassium-losing diuretics was observed.
Intention-to-treat analysis showed no significant difference in cardiovascular complications between ketanserin and placebo.
On-treatment analysis (excluding patients on diuretics) suggested a potential 25% reduction in thrombotic episodes with ketanserin.

Conclusions:

The combination of ketanserin and potassium-losing diuretics is undesirable due to safety risks.
Ketanserin may offer a benefit in reducing thrombotic episodes, warranting further investigation.
Future studies combining ketanserin with thromboxane A2 inhibitors are recommended.

Related Experiment Videos