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Serotonin and acute cardiovascular disorders.

R S Reneman1, P J van der Starre

  • 1Department of Physiology, University of Limburg, Maastricht, The Netherlands.

Cardiovascular Drugs and Therapy
|January 1, 1990
PubMed
Summary

Serotonin amplifies vasoconstriction, contributing to hypertension after cardiac surgery. Ketanserin, an S2-serotonergic antagonist, effectively treats this by blocking serotonin and alpha-1 adrenergic receptors.

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Area of Science:

  • Cardiovascular Physiology
  • Pharmacology

Background:

  • Systemic and pulmonary hypertension are acute complications following cardiac surgery.
  • Serotonin's role in postoperative hypertension is investigated, despite limited plasma level increases due to uptake by platelets and endothelial cells.

Purpose of the Study:

  • To discuss the role of serotonin in acute systemic and pulmonary hypertension after cardiac surgery.
  • To evaluate the efficacy of ketanserin in managing postoperative hypertension.

Main Methods:

  • Review of existing literature on serotonin's role in postoperative hypertension.
  • Analysis of ketanserin's effects as an S2-serotonergic and alpha-1 adrenergic receptor antagonist in patients with systemic and pulmonary hypertension.

Main Results:

  • Serotonin may amplify vasoconstriction caused by elevated epinephrine and norepinephrine.
  • Ketanserin effectively lowers arterial blood pressure in systemic postoperative hypertension.
  • Ketanserin is also effective in treating pulmonary hypertension post-valve replacement and reduces intrapulmonary shunting.

Conclusions:

  • Serotonin plays a role in postoperative hypertension through an amplifying effect on vasoconstriction.
  • Ketanserin demonstrates efficacy in treating both systemic and pulmonary hypertension after cardiac surgery.
  • Ketanserin's mechanism involves selective vasodilation and potential bronchodilation.

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