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Updated: May 19, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Ventilator-associated pneumonia: depends on your definition
Timothy J Novosel1, Laura A Hodge, Leonard J Weireter
1Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia, USA. tnovosel@hotmail.com
Abstract:
Reduction of hospital-acquired infections is a patient safety goal and regularly monitored by Performance Improvement committees. There is discordance between the ventilator-associated pneumonia (VAP) rate reported by the Infection Control Committee (ICC) and that observed by our Trauma Service. To investigate this difference, a retrospective evaluation of cases of VAP diagnosed on a single service was undertaken. A prospectively collected database was queried for VAP in intensive care unit patients between January 2010 and June 2011. This was compared with the list of mechanically ventilated patients provided by the ICC. Comparison for criteria used to diagnose pneumonia, ventilator day of the diagnosis, was recorded. The ICC identified two VAPs from 136 potential patients compared with the Trauma Service identifying 36 VAPs. A difference in diagnostic criteria between the ICC and the Trauma Service focused on use of the National Nosocomial Infection Survey (NNIS) algorithm versus quantitative microbiology from bronchoalveolar lavage specimens. Thirty-five of 36 Trauma Service VAPs were not identified as VAPs by the NNIS algorithm as a result of the chest radiographs. Application of differing definitions of VAP results in markedly different VAP rates. The difference has significant implications as infection rates are increasingly reported as a quality metric.
Insights
Different diagnostic criteria for ventilator-associated pneumonia (VAP) significantly impact reported infection rates. Trauma services identified 36 VAPs, while infection control reported only two, highlighting discrepancies in patient safety metrics.
Area of Science:
- Medical research
- Infectious disease epidemiology
- Patient safety
Background:
- Hospital-acquired infections are a key patient safety concern.
- Discrepancies exist in ventilator-associated pneumonia (VAP) rates reported by Infection Control Committees (ICC) and clinical services.
Purpose of the Study:
- To investigate the reasons for discordance in VAP rates between the ICC and the Trauma Service.
- To analyze the impact of differing diagnostic criteria on VAP surveillance.
Main Methods:
- Retrospective evaluation of VAP cases diagnosed by the Trauma Service.
- Comparison of VAP diagnoses with ICC data from January 2010 to June 2011.
- Analysis of diagnostic criteria, including the National Nosocomial Infection Survey (NNIS) algorithm and quantitative microbiology.
Main Results:
- The Trauma Service identified 36 VAPs, while the ICC identified only two among 136 potential patients.
- Differences in diagnostic criteria, particularly the use of chest radiographs in the NNIS algorithm, led to under-identification of VAP by the ICC.
- 35 of 36 VAPs identified by the Trauma Service were missed by the NNIS algorithm.
Conclusions:
- Varying definitions of VAP lead to significantly different reported infection rates.
- These discrepancies have substantial implications for quality metrics and patient safety reporting.
- Standardizing VAP diagnostic criteria is crucial for accurate surveillance and performance evaluation.
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