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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
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Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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Related Experiment Videos

Group A streptococcal panniculitis.

Jennifer Villaseñor-Park1, Amy Davis, Sonia Singh

  • 1Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Pediatric Dermatology
|August 4, 2012
PubMed
Summary
This summary is machine-generated.

Group A beta-hemolytic streptococcus rarely causes infectious panniculitis in healthy children. Skin biopsy confirmed deep lobular neutrophilic panniculitis with bacteria in a young girl.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Microbiology

Background:

  • Infectious panniculitis is an uncommon skin inflammation.
  • Group A beta-hemolytic streptococcus (GABHS) is a rare cause of panniculitis, particularly in immunocompetent individuals.

Observation:

  • A previously healthy 2-year-old girl presented with fever, rapid heart rate, and widespread red skin nodules.
  • Clinical symptoms were nonspecific, necessitating further investigation.

Findings:

  • Skin biopsy revealed deep lobular neutrophilic panniculitis.
  • Gram-positive bacteria, consistent with GABHS, were identified in the affected tissue.

Implications:

  • This case highlights the importance of considering GABHS in the differential diagnosis of infectious panniculitis, even in immunocompetent children.
  • Skin biopsy is crucial for identifying the causative agent and guiding treatment.
  • Early diagnosis and appropriate antibiotic therapy are essential for favorable outcomes.