Related Experiment Video
Updated: May 19, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
The p53 codon 72 polymorphism and the risk of oral cancer in a Chinese Han population
Guangping Jing1, Kewen Lv, Xiaohui Jiao
1Department of Oral Anatomy & Physiology, Stomatological College, Harbin Medical University, Harbin, China.
Background:
The p53 codon 72 polymorphism has been investigated extensively for its association with various cancers around the world. It is still unclear whether the p53 codon 72 polymorphism is associated with oral cancer risk.
Aim:
The aim of our study was to evaluate the association between the p53 codon 72 polymorphism and the oral cancer risk in Chinese Han patients.
Methods:
A hospital-based case-control study with 200 patients with oral cancer and 200 matched controls was conducted. Genomic DNA was isolated from peripheral blood, and gene polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism.
Results:
The arginine (Arg)/Arg genotype conferred 0.57 times reduced risk to oral cancer (95% confidence interval [CI]=0.36, 0.89; p=0.01). The Arg allele frequency was significantly lower (odds ratios [OR]=0.74, 95% CI=0.56, 0.98; p=0.03) in comparison with controls in patients with oral cancer. The proline allele frequency was significantly higher (OR=1.35, 95% CI=1.02, 1.79; p=0.03) in comparison with controls in patients with oral cancer. When stratified by the clinical stage, lymph node metastasis, and histological differentiation of oral cancer, no statistically significant results were observed.
Conclusion:
Our results thus suggest that the p53 codon 72 polymorphism modulates susceptibility to oral cancer in Chinese Han patients.
More Related Videos
07:00Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
04:56Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
Published on: December 30, 2025
Related Concept Videos
Abnormal Proliferation
Single Nucleotide Polymorphisms-SNPs
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Cancer Prevention
Some...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...