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Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Synteny and Evolution02:31

Synteny and Evolution

John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral chromosome underwent...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved DNA...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Updated: May 19, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
09:10

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

Published on: May 22, 2018

A web-based multi-genome synteny viewer for customized data.

Kashi V Revanna1, Daniel Munro, Alvin Gao

  • 1Department of Biological Sciences, University of North Texas, Denton, TX 76203, USA.

BMC Bioinformatics
|August 4, 2012
PubMed
Summary
This summary is machine-generated.

The multi-Genome Synteny Viewer (mGSV) allows biologists to visualize and analyze multiple genomes simultaneously. This web-based tool enhances data sharing and pattern discovery for genome conservation and rearrangements.

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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Last Updated: May 19, 2026

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Web-based synteny visualization tools are crucial for sharing genomic data and identifying conservation patterns.
  • Existing tools like GSV have limitations, primarily in comparing only two genomes at once.
  • The increasing volume of genomic data necessitates tools that can handle multiple genomes efficiently.

Purpose of the Study:

  • To develop an enhanced web-based tool for visualizing and analyzing multiple genomes.
  • To extend the functionality of the Genome Synteny Viewer (GSV) to accommodate multi-genome comparisons.
  • To provide biologists with a platform for uploading and analyzing their own genomic data.

Main Methods:

  • Development of the multi-Genome Synteny Viewer (mGSV), a web-based visualization tool.
  • Implementation of an enhanced user interface for integrated multi-genome views.
  • Provision of Web Services for machine-to-machine data transfer and an option for local installation.

Main Results:

  • mGSV enables the visualization of multiple genomes in a single, integrated view.
  • Users can examine conserved genomic regions and annotations across selected genomes in pairwise or multiple modes.
  • The tool supports both manual user interaction and automated data processing via Web Services.

Conclusions:

  • mGSV significantly improves upon the capabilities of the original GSV.
  • The developed tool facilitates advanced analysis of genome conservation and rearrangements across multiple species.
  • A web server for mGSV is available at http://cas-bioinfo.cas.unt.edu/mgsv.