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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: May 19, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
05:39

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Lentigo maligna.

E Samaniego1, P Redondo

  • 1Servicio de Dermatología, Complejo Asistencial Universitario de León, León, España.

Actas Dermo-Sifiliograficas
|August 4, 2012
PubMed
Summary
This summary is machine-generated.

Lentigo maligna, a melanoma in situ, requires early diagnosis and treatment to prevent invasive progression. This review examines diagnostic methods and surgical options for optimal patient management.

Keywords:
DiagnosisDiagnósticoLentigo malignaLentigo malignoTratamientoTreatment

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Area of Science:

  • Dermatology
  • Oncology
  • Surgical Pathology

Background:

  • Lentigo maligna is an early-stage melanoma primarily affecting sun-exposed skin in older adults.
  • It has a significant potential to progress to invasive lentigo maligna melanoma, carrying metastatic risk.
  • Current management strategies lack standardized guidelines and randomized trials.

Purpose of the Study:

  • To review diagnostic criteria and methods for lentigo maligna.
  • To evaluate surgical treatments and non-surgical alternatives for lentigo maligna.
  • To inform optimal management strategies for lentigo maligna.

Main Methods:

  • Literature review of diagnostic approaches for lentigo maligna.
  • Analysis of surgical techniques for lentigo maligna treatment.
  • Review of alternative therapies and their outcomes for lentigo maligna.

Main Results:

  • Early diagnosis is crucial for successful treatment and prevention of melanoma progression.
  • Surgery is the primary treatment, but alternatives exist with variable recurrence rates.
  • Evidence-based guidelines for lentigo maligna management are needed.

Conclusions:

  • Accurate diagnosis and timely intervention are key for lentigo maligna.
  • Surgical management offers the best outcomes, with alternatives considered when surgery is not feasible.
  • Further research is needed to establish definitive treatment protocols.