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High-performance liquid chromatography of globin chains in the identification of human globin gene abnormalities
1Istituto di Fisiologia Generale e Chimica Biologica, Università di Sassari, Italy.
Biophysical Chemistry
|August 31, 1990
Abstract:
This article summarizes experience and data obtained using a previously developed reverse-phase high-performance liquid chromatography method (J.B. Shelton, J.R. Shelton and W.A. Schroeder, J. Liq. Chromatogr. 7 (1984) 1969) in the study of a number of hemoglobinopathies in the Sardinian population. The occurrence and incidence of several abnormal hemoglobins are described, as well as aspects of the expression of abnormal gamma-globin gene arrangements and thalassemic genes.