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Management of primary vesicoureteral reflux in children: editorial commentary
Insights
Standardized treatment approaches are needed for children with vesicoureteral reflux (VUR). Understanding host defense abnormalities may lead to new therapies for recurrent urinary tract infections and kidney infections.
Area of Science:
- Pediatric Nephrology
- Urology
- Immunology
Background:
- Clinical management of pediatric vesicoureteral reflux (VUR) lacks standardization.
- Recurrent urinary tract infections (UTIs) in children may stem from host defense abnormalities.
- The host inflammatory response in kidney infections requires further investigation.
Abstract:
Decisions are needed about the clinical management of children with vesicoureteral reflux (VUR) and a standardized risk-specific treatment approach is needed. Clinicians and researchers must begin to think creatively about VUR. Clinicians are beginning to understand that there are a variety of abnormalities in specific host defenses that might predispose some children to recurrent urinary tract infection, and that knowledge of these deficiencies may lead to therapies designed to compensate for them. There is also much to be learned about host inflammatory response to kidney infection.
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