Chronic kidney disease predicts poor prognosis in patients with stable premature coronary artery disease

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Zhen Ding1, Xing Wang, Zhong Chen

  • 1Department of Cardiology, Affiliated Zhongda Hospital and School of Medicine, Southeast University, NO.87 Dingjiaqiao, Nanjing 210009, PR China.

European Journal of Internal Medicine
|August 4, 2012
PubMed

Insights

Chronic kidney disease (CKD) is prevalent in Chinese patients with premature coronary artery disease (CAD). CKD is linked to more risk factors and worse two-year cardiac outcomes.

Area of Science:

  • Cardiology
  • Nephrology
  • Public Health

Background:

  • Premature coronary artery disease (CAD) affects younger individuals and its association with chronic kidney disease (CKD) requires further investigation.
  • Understanding the prevalence and prognostic implications of CKD in stable, premature CAD patients is crucial for risk stratification and management.

Purpose of the Study:

  • To determine the prevalence of CKD in a Chinese population with stable, premature CAD.
  • To investigate the association between CKD and mid-term prognosis, specifically major adverse cardiac events (MACEs), in these patients.

Main Methods:

  • A cohort of 512 patients with stable, premature CAD in Jiangsu Province, China, were enrolled.
  • Chronic kidney disease (CKD) was identified using estimated glomerular filtration rate (eGFR).
  • Patients were followed for two years to record and analyze major adverse cardiac events (MACEs).

Main Results:

  • CKD was diagnosed in 35.74% of the patients.
  • CKD was associated with increased prevalence of type 2 diabetes mellitus, multi-vessel disease, higher fasting blood sugar, and lower left ventricular ejection fraction.
  • Patients with CKD experienced significantly higher composite MACEs at two-year follow-up (45.35% vs. 30.72%, P=0.001).
  • A decreased eGFR correlated with an increased incidence of MACEs.
  • Multivariate analysis identified CKD and multi-vessel disease as independent risk factors for MACEs.

Conclusions:

  • Stable, premature CAD patients with CKD in China present with a higher burden of cardiovascular risk factors.
  • CKD is independently associated with worse two-year cardiac outcomes in this population.
  • Early identification and management of CKD are critical for improving prognosis in patients with premature CAD.
Abstract

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