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Proteomic profiling implies mitochondrial dysfunction in tachycardia-induced heart failure.

Christoph Birner¹, Alexander Dietl, Rainer Deutzmann

¹Department of Internal Medicine II, University Regensburg, Regensburg, Germany. christoph.birner@klinik.uni-regensburg.de

Journal of Cardiac Failure

|August 4, 2012

Summary

Congestive heart failure alters protein expression in the ventricles, particularly affecting cellular energy metabolism. These changes differ between the left and right ventricles and between healthy and failing states.

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Area of Science:

Proteomics
Cardiovascular Biology
Molecular Mechanisms of Disease

Background:

Congestive heart failure (CHF) molecular mechanisms, especially protein expression changes, are not fully understood.
Investigating intraventricular and interventricular protein expression differences in heart failure is crucial.

Purpose of the Study:

To analyze intraventricular and interventricular protein expression differences in a rabbit model of tachycardia-induced heart failure.
To identify key proteins and pathways altered in left ventricular (LV) and right ventricular (RV) heart failure.

Main Methods:

Utilized a rapid ventricular pacing rabbit model to induce heart failure.
Employed 2D gel electrophoresis and MALDI-MS/MS for proteomic analysis and protein identification.

Main Results:

Heart failure induced by pacing showed LV dilatation, dysfunction, and hypotension.
LV-CHF revealed underexpression of proteins in cellular energy metabolism compared to LV-CTRL.
RV-CHF showed underexpression of respiratory chain proteins and nitric oxide pathway disturbances.
Failing LV exhibited stronger energetic pathways but underexpressed contractile/stress proteins compared to failing RV.
Differences in contractile, stress, and respiratory proteins were observed between control LV and RV tissues.

Conclusions:

Tachycardia-induced heart failure presents significant inter- and intraventricular protein expression alterations.
Protein expression changes predominantly involve pathways related to cellular energy metabolism.